Laboratory Billing & Coding: Reduce Denials, Get Paid Faster

Laboratory Billing and Coding Services: How They Can Reduce Claim Denials

By Henry Jensen on March 27, 2025

The financial sustainability of healthcare facilities depends largely on accurate Laboratory billing and coding. Coding mistakes create a financial waste of more than $36 billion every year, according to the American Health Information Management Association. Since laboratory services form a large part of medical services, with over 14 billion tests performed and 70% of medical decisions being dependent on lab results, accurate coding and billing practices become paramount. This contributes to prompt payment as well as increased efficiency in the delivery of healthcare services. 

In this blog, we will explore the process of Laboratory Medical Billing, providing you with solutions to the challenges in Lab billing. 

Why Is Laboratory Billing And Coding Important?

Laboratory medical billing plays a vital role in the healthcare revenue cycle, ensuring that labs receive timely and accurate reimbursements. According to the Centers for Medicare and Medicaid Services (CMS), healthcare spending exceeded $4.9 trillion in 2023, with laboratory services being a significant contributor.

However, without proper adherence to laboratory billing guidelines, errors in lab codes in medical billing can result in claim denials, delayed reimbursements, and compliance risks..

CPT Codes for Laboratory Billing

Test/PanelCPT CodesDescription
Basic Metabolic Panel (BMP)80047, 80048Measures glucose, calcium, electrolytes, and kidney function
Comprehensive Metabolic Panel (CMP)80053Includes BMP plus liver function tests
Lipid Panel80061Measures cholesterol and triglyceride levels
Complete Blood Count (CBC)85025, 85027Evaluates overall blood health
Thyroid Function Panel84436, 84439, 84443Measures T3, T4, and TSH levels
Hemoglobin A1c (HbA1c) Test83036Measures average blood sugar levels over 3 months
Urinalysis81001, 81002Measures average blood sugar levels over 3 months
COVID-19 Testing87635, U0003, U0004Detects SARS-CoV-2 virus in patients

ICD-10 Codes for Laboratory Billing

Condition/DiagnosisICD-10 CodesUsage
Diabetes, unspecifiedE11.9Used for routine diabetes management
Liver disease, unspecifiedK76.9Ordered for metabolic and liver function tests
Hyperlipidemia (High cholesterol)E78.5Helps assess cardiovascular disease risk
Iron deficiency anemiaD50.9Used with CBC to detect anemia
Hypothyroidism, unspecifiedE03.9Common for thyroid function panel
Diabetes with hyperglycemiaE11.65Essential for HbA1c testing
Urinary tract infection (UTI)N39.0Helps diagnose UTIs and kidney infections

Guidelines for Using Laboratory Panel Codes

Guidelines for Proper Use of Laboratory Panel Codes in Medical Billing
Essential laboratory panel codes and ensure compliant billing practices

Laboratory panel codes are essential for grouping multiple tests under a single billing code, simplifying the process for both providers and payers. Here are key guidelines to follow when using these codes:

Know the Panel Composition

Each laboratory panel consists of a specific set of tests bundled together. Ensure the tests included in the panel are accurately represented in the billing code. 

Use the Appropriate Panel Code

Only use the designated laboratory panel code when the full set of tests within the panel is performed. If some tests are not included, do not use the panel code, and instead bill each test individually.

Check Payer Guidelines

Different payers may have varying rules for which panels they cover or how they handle panel coding. Always check payer-specific guidelines to ensure correct billing and avoid denials.

Understand Modifier Use

Modifiers may be needed when a component of a panel is performed separately or when the panel is partially completed. Ensure modifiers are correctly applied based on the situation.

Ensure Proper Documentation

Proper documentation is critical. Ensure all the tests within the panel are clearly documented in the patient’s medical record. This supports accurate coding and minimizes the risk of claim denials.

Stay Current with Updates

Laboratory panel codes are periodically updated to reflect new tests or changes in medical guidelines. Regularly review updates from authoritative coding bodies (e.g., AMA, CMS) to ensure compliance.

Complete Laboratory Billing and Coding Process

Laboratory medical billing & coding is crucial; it ensures accurate and timely reimbursement and improves your practice’s financial stability. An efficient billing workflow minimizes claim denials, improves compliance, and accelerates revenue generation. Below is a comprehensive step-by-step process to improve the laboratory billing.

Patient Registration & Insurance Verification

The process begins with patient registration, which is a detailed verification of insurance information, demographic details, and eligibility. Pre-authorization may also be required for certain laboratory tests to avoid claim rejections. 

Conducting Laboratory Tests

Healthcare providers order specific lab tests based on the patient’s medical condition. Laboratories must ensure CLIA compliance and proper documentation of tests performed.

Documentation & Compliance Check

All test results, medical history, and physician orders must be documented accurately. This step ensures compliance with CMS, HIPAA, and payer-specific laboratory billing guidelines, reducing the risk of claim denials.

Assigning CPT & ICD-10 Codes

Medical coders review the documentation and assign appropriate ICD-10 diagnosis codes and CPT (Current Procedural Terminology) codes to reflect the performed laboratory services. Incorrect coding can lead to denials, underpayments, or legal penalties.

Claim Preparation & Submission

The coded data is used to generate claims, which are submitted electronically or manually to insurance companies. Ensuring clean claims with accurate modifiers improves first-pass acceptance rates.

Payer Adjudication & Compliance Review

Insurance companies verify submitted claims against policy guidelines. If a claim meets compliance standards, it is processed for payment; otherwise, it may be denied or returned for corrections.

Payment Posting & Patient Billing

Once the payer processes the claim, payments are posted to the laboratory’s billing system. Any remaining patient balance, including co-payments and deductibles, is billed directly to the patient.

Denial Management & Appeals

In case of claim denials, billing specialists analyze the denial reasons, make necessary corrections, and resubmit appeals to recover payments. Timely follow-ups with payers ensure minimal revenue losses.

Audit & Compliance Monitoring

Regular internal audits help identify coding errors, fraudulent claims, or upcoding/downcoding issues. Laboratories must adhere to HIPAA, CLIA, and CMS guidelines to avoid compliance violations.

Using Automation & Billing Software

To reduce administrative burdens, laboratories use billing automation tools like Kareo, Xifin, and AdvancedMD to improve coding, claims submission, and revenue tracking. Automated systems enhance accuracy and reduce claim rejections by up to 40%

3 Essential Tools to Improve Laboratory Billing

Essential Tools to Improve Laboratory Billing Efficiency and Accuracy
Essential tools to optimize revenue in laboratory billing

Whether handling billing in-house or outsourcing, the right tools can optimize your practices, improve reimbursements, and reduce costs. Here are three key tools to enhance your laboratory billing:

  • Laboratory Information System (LIS)

A strong LIS helps identify revenue cycle issues, analyze past data, and predict future performance. It improves procedures to reduce claim denials and increase profits.

  • Instant Adjudication

Automated eligibility tools allow you to verify patient coverage, file claims, and receive responses in real time, improving claim flow and efficiency.

  • ICD-10 Converter Software

For smaller labs, ICD-10 conversion software helps accurately code up to 10,000 diagnoses, reducing errors and claim denials.

Overcoming Common Challenges in Laboratory Billing

Overcoming Common Challenges in Laboratory Billing – Maximize Efficiency and Revenue
Address common issues in laboratory billing with proven strategies to reduce claim denials, improve accuracy, and enhance revenue cycle efficiency.

Revenue cycle management (RCM) is critical to healthcare operations, but balancing patient care with administrative tasks can lead to billing challenges. Here are the key issues healthcare providers face and how to address them.

1. Insurance Verification Issues

Patients often forget to update their insurance details, leading to billing errors. A reliable insurance verification system at each visit ensures accurate claims.

2. Patient Communication Gaps

Clear communication about patient financial responsibilities is essential. Informing patients upfront about potential charges prevents billing disputes later.

3. Outdated Billing Codes

Billing codes and insurance rules change frequently. Keeping up with these updates is crucial to avoid claim rejections, requiring continuous education and updated software tools.

4. Manual Data Entry Errors

Relying on manual, paper-based processes increases the risk of mistakes. Switching to automated billing software streamlines data entry, reduces errors, and saves time.

5. Lack of a Review Process

Without a thorough review process, providers risk missing recurring billing issues. Establishing regular audits and reviewing unpaid claims helps prevent revenue loss.

Best Practices for Optimizing Laboratory Billing

To ensure that your laboratory billing processes are running smoothly and efficiently, here are some key best practices to follow:

Ongoing Training and Education

Regular training sessions and educational updates for your billing team can ensure they are always prepared for changes in the billing landscape.

Conduct Regular Audits

Routine internal and external audits are invaluable for spotting coding errors, compliance issues, and potential missed revenue opportunities. 

Investing in Technology

Tools can eliminate much of the manual work, reduce errors, and improve billing efficiency, allowing your team to focus on more strategic tasks.

Strengthen Team Communication

Establishing clear communication channels and ensuring that everyone is on the same page with medical documentation helps eliminate errors and improve the accuracy of submitted claims.

Consider Outsourcing Your Billing

Outsourcing laboratory billing to a third-party professional company can offer significant advantages, including cost savings and increased efficiency. 

Future Trends in Laboratory Billing and Coding

Laboratory billing and coding are evolving with healthcare advancements. Here are key trends to watch:

Increased Automation

Automation in billing and coding will streamline claim processing, reduce errors, and speed up reimbursement cycles.

AI in Coding

AI will enhance coding accuracy by analyzing records and automatically assigning codes, improving efficiency and compliance.

Telemedicine Integration

With the rise of telemedicine, laboratories will need to adapt billing processes for remote tests and virtual consultations.

Value-Based Care

As healthcare shifts to value-based care, laboratories will focus on coding for patient outcomes rather than volume.

Data Security

With digital systems growing, laboratories will prioritize cybersecurity to protect patient data and comply with regulations.

Final Thoughts: 

Effective laboratory billing and coding are essential for ensuring financial stability, reducing claim denials, and maintaining compliance with industry regulations. By following best practices such as accurate coding, automation, regular audits, and clear communication, laboratories can improve their revenue cycle and optimize reimbursements. Whether managing billing in-house or outsourcing, investing in the right tools and processes will help laboratories enhance efficiency, minimize errors, and ensure continued financial success.

Why Choose CloudRCM for Laboratory Medical Billing and Coding?

Managing laboratory billing and coding can be complex, with evolving regulations, changing CPT and ICD-10 codes, and increasing payer scrutiny. CloudRCM simplifies this process with cutting-edge technology, expert support, and a results-driven approach. Here’s why CloudRCM stands out:

  • Expertise in Laboratory Billing
  • Advanced Automation & AI-Powered Billing 
  • Real-Time Insurance Verification
  • Transparent Revenue Cycle Management (RCM)
  • Faster Reimbursements with Instant Adjudication
  • Customized Solutions for Every Laboratory
  • Dedicated Support & Compliance Assurance

Laboratory Medical Billing and Coding: FAQs

What are CLIA requirements in laboratory billing?

CLIA (Clinical Laboratory Improvement Amendments) regulations ensure labs meet federal quality standards for accurate testing and billing.

What is the role of HIPAA in laboratory billing?

HIPAA ensures patient data privacy and secure electronic transactions in laboratory billing and coding.

What are common reasons for claim denials in lab billing?

Claim denials occur due to incorrect coding, lack of medical necessity, missing documentation, or duplicate billing.

What is the role of ICD-10 codes in lab billing?

ICD-10 codes indicate the medical necessity of a laboratory test by linking it to a diagnosis.

Henry Jensen

Henry Jenson is the creative mind behind the messaging at CloudRCM Solutions, where he crafts compelling content that bridges the gap between technology and healthcare. With a rich background spanning multiple sectors of the industry, he thrives on solving the intricate challenges that medical practices and billing organizations face.

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